Total synthesis of twenty-five picrotoxanes by virtual library selection
The synthesis of a complex molecule begins from an initial design stage1,2,3,4 in which possible routes are triaged by strategy and feasibility, based on analogy to similar reactions.2,3 However, as molecular complexity increases, predictability decreases;5 inevitably, even experienced chemists resort to trial-and-error to identify viable intermediates en route to the target molecule. We encountered such […]
