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Nature, Published online: 17 December 2024; doi:10.1038/d41586-024-04102-w Gene-editing technologies for cancer and blood disorders are maturing a little more than a year after the first CRISPR drug was approved.
Skin can generate antibodies, independent of the rest of the immune system.Credit: kazuma seki/Getty The skin — once thought to be a mainly passive barrier — can produce its own antibodies that fight off infections, a pair of studies reports in Nature this week1,2. The findings could pave the way for the development of needle-free […]
Nature, Published online: 04 December 2024; doi:10.1038/d41586-024-03846-9 The discovery that peptides from myelin proteins in the brain help the immune system’s T cells to suppress autoimmunity could pave the way to developing therapies for inflammatory brain diseases.
NEWS AND VIEWS 04 December 2024 During some types of cell death, cells rupture to release molecules that cause inflammation. This must happen at the right time and place to restore health. How is the protein NINJ1 regulated so that cells break open only when they die?
From roundworms to humans, signalling through the Notch protein-receptor family drives embryonic development, cellular differentiation and tissue homeostasis. It’s also absolutely essential for the transformation of immature human immune cells into T cells — cellular warriors that target viruses and tumours. Yet the activation of Notch signalling has been hard to mimic in the laboratory, […]
RESEARCH BRIEFINGS 06 November 2024 The body’s clock is essential for anticipating daily environmental changes. Surprisingly, clock genes are highly expressed in innate immune cells that produce the inflammatory protein interleukin-17A, particularly in body fat. The clock drives a rhythmic production of this protein, which in turn contributes to the metabolic rhythms of fat.
Platelets and red blood cells mingle in a blood clot (artificially coloured).Credit: Anne Weston, EM STP, The Francis Crick Institute/Science Photo Library Chicago, Illinois Forget the gauze and bandages: electrical stimulation near the ear might help to reduce bleeding. Researchers hope the technique could one day be used before surgery, childbirth and other events that […]
