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Science

Paradoxical link between senescent cell state and liver cancer resolved

RESEARCH BRIEFINGS 01 January 2025 Metabolic-dysfunction-associated steatohepatitis (MASH) is defined by lipid accumulation and inflammation, and makes liver cells enter a tumour-suppressive state called senescence while increasing cancer risk. Investigation of this paradox reveals that MASH-inducing diets trigger senescence by causing DNA damage. However, prolonged metabolic stress allows once-senescent liver cells to start dividing and […]

10 Mayo Clinic research advances in 2024, spanning stem cell therapy in space to growing mini-organs

ROCHESTER, Minn. — At Mayo Clinic, researchers published more than 10,000 scientific papers in 2024 that are driving medical discoveries, leading to new cures for the future. The following are 10 research highlights from Mayo Clinic this year: Microscopic view of an intestinal organoid Growing mini-organs to find new treatments for complex disease Mayo Clinic investigators […]

Science

M87* lashes out; a deep sleep discovery; proposal to build a digital cell

Light curve of the gamma-ray flare (bottom) and collection of quasi-simulated images of the M87 jet (top) at various scales obtained in radio and X-ray during the 2018 campaign. The instrument, the wavelength observation range and scale are shown at the top left of each image. Credit: EHT Collaboration, Fermi-LAT Collaboration, H.E.S.S. Collaboration, MAGIC Collaboration, […]

Science

Scientists develop ultrasound-based technique as a tool for directing cell growth and orientation

Using a simple yet effective technique, researchers from Doshisha University could harness ultrasound vibrations generated by a piezoelectric transducer to control the orientation of cultured myoblasts. After optimizing different timing, frequency, and intensity configurations, they developed a method to induce myoblasts to differentiate into circumferentially aligned myotubes. Credit: Daisuke Koyama / Doshisha University, Japan Developing […]

Innovative blood analysis technique reveals insights into giant cell arteritis

Mayo Clinic researchers have identified key protein patterns in the blood that could improve how doctors diagnose and monitor giant cell arteritis, a chronic autoimmune disease that causes inflammation in blood vessels. The condition often affects arteries in the head and can lead to vision loss or stroke if untreated. The new research, led by […]

Science

Computational technologies of the Human Cell Atlas

Single-cell technologies have shattered the fuzzy lenses through which researchers conventionally view biology. Instead of looking at the average behaviour of a swathe of cells, scientists can interrogate genes or other features cell by cell. But the technology also brings challenges: the data are expensive to collect and analyse, and typically force researchers to choose […]