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Science

Computational technologies of the Human Cell Atlas

Single-cell technologies have shattered the fuzzy lenses through which researchers conventionally view biology. Instead of looking at the average behaviour of a swathe of cells, scientists can interrogate genes or other features cell by cell. But the technology also brings challenges: the data are expensive to collect and analyse, and typically force researchers to choose […]

Science

Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Samples from paediatric patients with ALL and HDs The current study is a secondary investigation using patient samples collected from an existing clinical trial for which the University of Pennsylvania Institutional Board provided insight. Pre-infusion samples of CAR T cells were obtained from patients with relapsed/refractory B-ALL, participating in either a phase I/IIA pilot clinical […]