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James Cook Over/Under 64.5 Rushing Yards
James Cook has been a bit of a boom-or-bust player out of the Buffalo backfield in 2024.
He has five games with 70+ rushing yards, but he also has five games with fewer than 45 yards on the ground.
Additionally, four of Cook’s five best rushing performances came away from Buffalo. He’s only had more than 45 rushing yards at home once this season.
The good news for Cook is that the 49ers have allowed over 100 rushing yards in three of their five road games.
The 49ers have one of the better rushing defense as a whole, but they’ve been exploited a bit when they travel.
Khalil Shakir Over/Under 5.5 Receptions & Over/Under 54.5 Receiving Yards
Khalil Shakir is Josh Allen’s top target in the passing game.
He will have even more importance through the air on Sunday with Keon Coleman listed as questionable and Dalton Kincaid out.
Shakir cleared over 5.5 receptions in each of the last five games. He was targeted at least seven times in all of those contests.
The yardage production has been consistent as well. He had at least 50 receiving yards in every game of that five-game run.
The over on Shakir’s receptions and receiving yards should be in play as long as the conditions don’t severely limit the passing attacks of both teams.
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